Triazole compounds having antifungal properties
AssigneeTakeda Chemical Industries, Ltd.
InventorsKatsumi Itoh, Kenji Okonogi
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Abstract
The novel azole compounds of the formula: ##STR1## wherein Ar stands for substituted phenyl; R.sup.1, R.sup.2 and R.sup.3 independently stand for a hydrogen atom or a lower alkyl group; B stands for a hydroxyl group or an organic residue bonded through a carbon atom; X stands for a CH group or a nitrogen atom; m denotes an integer of 1 to 4; n denotes an integer of 0 to 2, provided that, when B is a hydroxyl group, n is 2, or a physiologically acceptable salt thereof have antifungal activities, and they are used preventing or treating infectious diseases caused by fungi.
Claims22
A compound of the formula:
- ##STR59## wherein Ar stands for a phenyl having 1 to 3 substituents independently selected from halogen and trifluoromethyl;
- R.sup.1, R.sup.2 and R.sup.3 independently stand for a hydrogen atom or a lower alkyl group;
- Q stands for a group represented by the formula:
- ##STR60## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are of the same meaning as defined above;
- X' is a CH group or a nitrogen atom;
- X stands for a nitrogen atom;
- m denotes an integer of 1 to 4;
- n denotes an integer of 0 to 2, or a physiologically acceptable salt thereof.
A compound according to claim 19, wherein both the carbon bonded to hydroxyl and Ar groups and the carbon bonded to hydroxyl and Ar groups and the carbon bonded to R.sup.3 are of R-configuration.
An antifungal composition which contains an effective amount of a compound of the formula:
- ##STR61## wherein Ar stands for a phenyl having 1 to 3 substituents independently selected from halogen and trifluoromethyl;
- R.sup.1, R.sup.2 and R.sup.3 independently stand for a hydrogen atom or a lower alkyl group;
- Q stands for a group represented by the formula:
- ##STR62## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are of the same meaning as defined above;
- X' is a CH group or a nitrogen atom;
- X stands for a nitrogen atom;
- m denotes an integer of 1 to 4;
- n denotes an integer of 0 to 2, or a pharmacologically acceptable salt thereof, and a pharmacologically acceptable carrier.
Dependencies are inferred from the claim text.