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US 5,177,092 AGranted
Medicinal use of certain tetrazolium salts
AssigneeMerck & Co., Inc.
InventorsDavid C. Remy, John J. Baldwin, David A. Claremon, Stella W. King
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Abstract
Azole compounds including azoles and azolium salts, and their use as transglutaminase inhibitors are disclosed.
Claims2
A method for inhibiting hard clot formation or supplementing fibrinolytic therapy comprising administering to a patient in need of such treatment an amount of tetrazolium salt effective for inhibiting hard clot formation or supplementing fibrinolytic therapy wherein said tetrazolium salt is represented by the formula ##STR49## wherein Az is a tetrazolium nucleus
- R' and R" indenpendently are lower alkyl from 1 to 5 carbon atoms;
- phenyl;
- substituted phenyl containing from 1 to 3 substituents selected from lower alkyl, lower alkoxy, halo and hydroxy;
- benzyl;
- or phenylethyl;
- R is hydrogen, lower alkyl from 1 to 5 carbon atoms;
- cycloalkyl from 3 to 7 carbon atoms;
- phenyl;
- or substituted phenyl containing from 1 to 3 substituents selected from lower alkyl, lower alkoxy, halo and hydroxy;
- and
- X is a negative radical of a pharmaceutically acceptable acid.
8 more elements
Dependencies are inferred from the claim text.