Butenoic or propenoic acid derivative
AssigneeEisai Co., Ltd.
InventorsNorio Minami, Fumihiro Ozaki, Keiji Ishibashi, Yasuhiro Kabasawa, Megumi Ikemori, Toshiaki Ogawa, Takanori Kawamura
Life of this patent
Estimating the term…
Abstract
A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field. ##STR1##
Claims9
A butenoic or propenoic acid derivative having the formula ##STR318## wherein R.sup.1 is a pyridyl group, R.sup.2 and R.sup.3 each are hydrogen, a lower alkyl, a cycloalkyl or an alkyl group;
- A is an alkylene group having 1 to 6 carbon atoms wherein said alkylene may have a lower alkyl, a lower alkoxy or a hydroxy attached thereto, J is a phenyl group having substituents R.sup.4, R.sup.5 and R.sup.6 ##STR319## wherein R.sup.4, R.sup.5 and R.sup.6 each are H, halogen, a lower alkyl , a lower alkoxy, a hydroxy, nitro, cyano, trifluoromethyl, an alkylsulfonyloxy, --NR.sup.7 R.sup.8 wherein R.sup.7 and R.sup.8 is hydrogen, lower alkyl or alkanoxylamino, or two of R.sup.4, R.sup.5 and R.sup.6 may form an alkylenedioxy together with two adjacent carbon atoms on the phenyl ring, or R.sup.4, R.sup.5 and R.sup.6 may form a 5- to 7-membered carbocyclic ring together with --(CH.sub.2)--;
- and n is an integer of 1 to 6;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.