Cyclic amine compounds and their use
AssigneeTakeda Chemical Industries, Ltd.
InventorsGiichi Goto, Hidefumi Yukimasa, Tetsuji Imamoto
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AssigneeTakeda Chemical Industries, Ltd.
InventorsGiichi Goto, Hidefumi Yukimasa, Tetsuji Imamoto
Estimating the term…
There is provided a cyclic amine compound of the formula ##STR1## wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, means either a single bond or a double bond (provided that when A means a bond, means a single bond); R.sub.2 and R.sub.3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R.sub.2 and R.sub.3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof. The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.
A compound which is ##STR201## wherein R.sub.1 " is hydrogen or benzyl of which the phenyl ring may be optionally substituted with from one to three substituents selected from C.sub.1-3 alkoxy groups, C.sub.1-3 alkyl groups, cyano, hydroxy, nitro and halogens;
Dependencies are inferred from the claim text.