Huperzines and analogs
OwnerChao-mei Yu, Xi-can Tang +2inventors
InventorsChao-mei Yu, Xi-can Tang, Jia-sen Liu, Yan-yi Han
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Abstract
The invention relates to compounds of the formulas ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or lower alkyl, and the dotted ( . . . ) line is an optional double bond, and their pharmaceutically acceptable acid addition salts. The compounds of formulas I, II and III possess marked anticholinesterase activity and are useful as analeptic agents and as agents for the treatment of senile dementia and myasthenia gravis.
Claims10
Essentially pure (4aR, 5R, 10bR)-1,2,3,4,4a,5,6,10b-octahydro-12-methyl-5,10b-propeno-1,7-phenanthrol in-8(7H)-one.
A pharmaceutically acceptable acid addition salt of (4aR, 5R, 10bR)-1,2,3,4,4a,5,6,10b-octahydro-12-methyl-5,10b-propeno-1,7-phenanthrol in-8(7H)-one.
A compound of the formula ##STR4## wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or lower alkyl, the dotted ( . . . ) line is an optional double bond, and provided that in formula III one of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, or a pharmaceutically acceptable acid addition salt thereof.
A pharmaceutical composition comprising an effective amount of an essentially pure compound of a formula ##STR7## wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or lower alkyl, and the dotted ( . . . ) line is an optional double bond, or a pharmaceutically acceptable acid addition salt thereof and an inert pharmaceutical carrier.
Dependencies are inferred from the claim text.