2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
AssigneeWarner-Lambert Company
InventorsDavid T. Connor, Catherine R. Kostlan
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Abstract
The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenease and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
Claims9
A compound of the formula I ##STR14## or a pharmaceutically acceptable salt, or hydrate thereof;
- wherein n is an integer of zero or one;
- W is pyridinyl or pyridinyl substituted by lower alkyl on one or more of a ring carbon atom.
Dependencies are inferred from the claim text.