Piperazine derivatives
AssigneeJohn Wyeth & Brother Limited
InventorsTerence J. Ward, Graham J. Warrellow
Life of this patent
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Abstract
Compounds of formula ##STR1## where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is hydrogen or lower alkyl, R.sup.1 is an aryl or heteroaryl radical, R.sup.2 is a mono- or bicyclic heterocyclic radical, R.sup.3 is hydrogen, lower alkyl or hydroxy and R.sup.4 is a aryl or heteroaryl radical, and their pharmaceutically acceptable acid addition salts are 5-HT.sub.1A binding agents which may be used, for example, for the treatment of CNS--disorders such as anxiety.
Claims18
A compound of the formula ##STR16## wherein A is --CH.sub.2 --, --CHCH.sub.3 --, --C(CH.sub.3).sub.2, --CH.sub.2 CH.sub.2 --, CH.sub.2 -CH(CH.sub.3)--, CH(CH.sub.3 -CH(CH.sub.3)--, and --CH.sub.2 --C(CH.sub.3).sub.2 --,
- R is hydrogen or lower alkyl,
- R.sup.1 is an aryl or a mono- or bicyclic heteroaryl radical of from 5 to 11 ring atoms having one or two hetero atoms independently selected from N, O or S, or having three or four N atoms, which may be optionally substituted as for aryl,
- R.sup.2 is a mono- or bicyclic heterocyclic radical of from 5 to 11 ring atoms having one or two hetero atoms selected from N, O or S which may be optionally substituted as for aryl,
- R.sup.3 is hydrogen or lower alkyl, and
- R.sup.4 is aryl or a mono- or bicyclic heteroaryl radical of from 5 to 11 ring atoms having one or two hetero atoms selected from N, O or S which may be optionally substituted as for aryl, wherein aryl refers to an aromatic radical having 6 to 12 carbon atoms which may be optionally substituted by one to three substituents selected from lower alkyl, lower alkoxy halogen halo(lower)akyl, nitro, amino, mono- or di-(lower)alkylamino.
Dependencies are inferred from the claim text.