Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives

A method of treating a mammal for a disease state selected from the group consisting of:

• autoimmune disease, inflammatory disease, and psoriatic disease, which comprises administering a therapeutically effective amount of a compound represented by the formula:
• ##STR16## wherein:
• m is an integer from two to four;
• Z is selected from formulae (a), (b), (c), or (d), as follows:
• (a) ##STR17## in which:
• R.sup.1 is hydrogen, alkyl or cycloalkyl having seven or more carbon atoms, or --NR.sup.2 R.sup.3, in which;
• R.sup.2 is hydrogen or lower alkyl, and
• R.sup.3 is hydrogen, lower alkyl, -phenyl--CO.sub.2 R.sup.2, or a pharmaceutically acceptable cation;
• (b) ##STR18## in which:
• R.sup.4 is hydrogen, alkyl, aryl, or --NR.sup.2 R.sup.3 ;
• (c) ##STR19## in which:
• n is an integer from zero to six, and R.sup.5 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation;
• (d) ##STR20## in which:
• R.sup.6 and R.sup.7 are independently hydrogen or --CO.sub.2 R.sup.5 ;
• and
• Y is lower alkylene of four to six carbon atoms, or lower alkylene of three to five carbon atoms plus one member that is --O--, --S--, or --N(R.sup.8)-- where R.sup.8 is hydrogen or alkyl of one to five carbon atoms;
• or a pharmaceutically acceptable salt thereof.