Back to results
US 5,177,069 AGranted
Naphthysulfonylalkanoic acid compounds and pharmaceutical compositions thereof
AssigneeKissei Pharmaceutical Co., Ltd.
InventorsMakio Kitazawa, Masuo Akahane, Yasushi Nakano, Atsushi Tsubaki, Kazuaki Sato, Masaaki Ban, Michihiro Kobayashi
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel class of naphthylsulfonylalkanoic acid compounds such as a structure corrresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention naphthylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.
Claims7
A compound represented by the formula:
- ##STR30## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkenyloxy group having 3 to 6 carbon atoms, an acyloxy group having 2 to 5 carbon atoms, a carboxy group, an alkoxycarbonyl group having 2 to 7 carbon atoms, a carbamoyl group of the formula ##STR31## in which R.sup.4 and R.sup.5 are the same or different and are a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, a group of the formula ##STR32## in which X is a single bond, --CH.sub.2 -- or --O--, p and q are the same or different and are an integer of from 0 to 3, with the proviso that the sum of p and q is 2 to 5, or a lactam group of the formula ##STR33## in which r is an integer of from 2 to 5;
- R.sup.2 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkenyloxy group having 3 to 6 carbon atoms, an acyloxy group having 2 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 7 carbon atoms;
- R.sup.3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a benzyl group;
- 1 and m are the same or different and are an integer of from 1 to 4;
- n is 1 or 2;
- and pharmaceutically acceptable salts thereof.
3 more elements
A compound represented by the formula:
- ##STR34## and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.