Substituted aminoalkyl biphenyl compounds and method of treating fungal infections

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of the formula ##STR12## wherein R.sup.1 and R.sup.2 each independently are hydrogen, C.sub.1-7 -alkyl or C.sub.2-7 -alkenyl, or together are a straight chain C.sub.2-4 -alkylene;

• R.sup.3 and R.sup.4 each independently are hydrogen or C.sub.1-7 -alkyl;
• R.sup.5 and R.sup.6 each independently are hydrogen, halogen, trifluoromethyl, nitro, cyano, C.sub.1-7 -alkoxy or C.sub.1-7 -alkyl;
• and Q is an unsubstituted or substituted phenyl or naphthyl group, wherein the substituents are at least one of halogen, trifluoromethyl, cyano, nitro, C.sub.1-7 -alkyl, or C.sub.1-7 -alkoxy;
• C.sub.2-10 -alkenyl;
• or a hydroxy-substituted or unsubstituted C.sub.1-10 -alkyl group;
• or a pharmaceutically acceptable acid addition salt thereof.

A pharmaceutical composition comprising a effective amount of a compound of the formula ##STR13## wherein R.sup.1 and R.sup.2 each independently are hydrogen, C.sub.1-7 -alkyl or C.sub.2-7 -alkenyl, or together are a straight chain C.sub.2-4 -alkylene;

• R.sup.3 and R.sup.4 each independently are hydrogen or C.sub.1-7 -alkyl;
• R.sup.5 and R.sup.6 each independently are hydrogen, halogen, trifluoromethyl, nitro, cyano, C.sub.1-7 -alkoxy or C.sub.1-7 -alkyl;
• and Q is an unsubstituted or substituted phenyl or naphthyl group, wherein the substituents are at least one of halogen, trifluoromethyl, cyano, nitro, C.sub.1-7 -alkyl, or C.sub.1-7 -alkoxy;
• C.sub.2-10 -alkenyl;
• or a hydroxy-substituted or unsubstituted C.sub.1-10 -alkyl group;
• or a pharmaceutically acceptable acid addition salt thereof and an antimycotically active compound which inhibits the biosynthesis of sterols.

A method of controlling or preventing topical or systemic fungal infections in a patient which comprises administering to said patient in need of such treatment an effective amount of a compound of the formula ##STR14## wherein R.sup.1 and R.sup.2 each independently are hydrogen, C.sub.1-7 -alkyl or C.sub.2-7 -alkenyl, or together are a straight chain C.sub.2-4 -alkylene;

• R.sup.3 and R.sup.4 each independently are hydrogen or C.sub.1-7 -alkyl;
• R.sup.5 and R.sup.6 each independently are hydrogen, halogen, trifluoromethyl, nitro, cyano, C.sub.1-7 -alkoxy or C.sub.1-7 -alkyl;
• and Q is an unsubstituted or substituted phenyl or naphthyl group, wherein the substituents are at least one of halogen, trifluoromethyl, cyano, nitro, C.sub.1-7 -alkyl, or C.sub.1-7 -alkoxy;
• C.sub.2-10 -alkenyl;
• or a hydroxy-substituted or unsubstituted C.sub.1-10 -alkyl group;
• or a pharmaceutically acceptable acid addition salt thereof.