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US 5,177,060 AGranted
Anti-inflammatory peptides and treatment to inhibit vascular leakage in injured tissues
AssigneeThe Regents of the University of California
InventorEdward T. Wei
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Abstract
Relatively small, synthetic anti-inflammatory peptides are provided having the primary sequence T.sub.N --A.sub.1 --A.sub.2 This invention was made with Government support under Grant No. DA-00091 awarded by the National Institutes of Health. The Government has certain rights in this invention.
Claims4
A peptide having the primary structure:
- T.sub.N --A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --T.sub.C
- where T.sub.N is an amino terminal portion having a molecular weight less than about 600 daltons and is selected to convey resistance against enzymatic degradation,
- T.sub.C is D-leucineamide or phenylalanine,
- A.sub.1 is D- or L- arginine or lysine,
- A.sub.2 is D- or L- arginine or lysine,
- A.sub.3 is D- or L- methionine, leucine or isoleucine,
- A.sub.4 is D- or L- isoleucine, leucine, or methionine,
- A.sub.5 is D- or L- glutamic acid, glutamine, or aspartic acid, and
- A.sub.6 is D- or L- isoleucine, leucine, or asparagine.
6 more elements
Dependencies are inferred from the claim text.