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US 5,177,059 AGranted
Polymyxin B conjugates
AssigneeSandoz Ltd.
InventorsDean A. Handley, Philip Lake
Life of this patent
Estimating the term…
Abstract
Polymyxin B carrier conjugates, especially polymyxin B-dextran, are water soluble, have a greater half-life in the bloodstream and are significantly less toxic than native polymyxin B.
Claims16
A conjugate comprising Polymyxin B and a carrier, wherein said conjugate is soluble in water and of a size suitable for delivery and circulation in the blood stream of a human or animal, said conjugate having anti-endotoxin activity and comprising a molecular ratio of said Polymyxin B to said carrier from about 1:15 to about 200:1.
Polymyin B-dextran conjugate produced by a process comprising:
- a) conjugating PMB to dextran to form a PMB-dextran conjugate;
- said conjugate comprising a molecular ratio of PMB to dextran from about 1:15 to about 200:1 and being soluble in water and of a size suitable for delivery and circulation in the blood stream and
- b) purifying said conjugate by precipitating the conjugate in a lower alcohol;
- c) resuspending the conjugate;
- and
- d) repeating steps b) and c) until the conjugate is substantially free from unbound PMB.
3 more elements
Dependencies are inferred from the claim text.