Pharmaceutical formulation for the treatment of diabetes mellitus
AssigneeHoechst Aktiengesellschaft
InventorMichael Dorschug
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Abstract
Pharmaceutical formulations for the treatment of diabetes mellitus are disclosed, wherein the pharmaceutical formulations contain at least one insulin derivative modified with a base in position B31 of the insulin B chain and having an isoelectric point between 5.8 and 8.5 and/or at least one of its physiologically tolerated salts in a pharmaceutically acceptable excipient and a relatively high zinc ion content in the range from above 1 .mu.g to about 200 .mu.g of zinc/IU. The preferred insulin derivative modified with a base for this pharmaceutical formulation is human insulin-B31-Arg-OH and human insulin-B31-Arg-B32-Arg-OH. The formulation is used for the treatment of diabetes mellitus; it has a particularly favorable action profile.
Claims11
A pharmaceutical formulation containing at least one insulin derivative modified with a base and having an isoelectric point between 5.8 and 8.5, of the formula I ##STR3## in which R.sup.1 denotes H or H-Phe, R.sup.30 represents the radical of a neutral, genetically encodable L-amino acid and
- R.sup.31 represents a physiologically acceptable organic group of basic character having up to 50 carbon atoms, in the build-up of which 0 to 3 .alpha.-amino acids participate and in which any terminal carboxyl function present can be free, or reduced to CH.sub.2 OH,
- and containing at least one of its physiologically tolerated salts in a pharmaceutically acceptable excipient with a content of zinc ions,
- in which the zinc ion content is in a range from 4.0 .mu.g to about 200 .mu.g of zinc/IU.
Dependencies are inferred from the claim text.