Stable immunogen composition for oral administration
AssigneeThe Nisshin Oil Mills, Ltd.
InventorsKuniaki Nerome, Kuniharu Seki, Katsuhiko Ohyama
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Abstract
A stable immunogen composition for oral administration which includes a dried spherical form comprised of an immunogen capable of immunizing human or animals and a gelatin having an average molecular weight of 80,000-120,000 and jelly strength of more than 150 (Bloom, g, 6.2/3%), and is enteric.
Claims14
A stable immunogen composition for oral administration which comprises a dried spherical form comprising an immunogen which immunizes humans or animals and a gelatin having an average molecular weight of 80,000-120,000 and jelly strength of from 150 to 340 (Bloom, g, 6.multidot.2/3%), and is enteric, wherein an amount of the immunogen used is 1/50-1/100,000,000 by weight relative to that of the gelatin.
A process for the preparation of a stable immunogen composition for oral administration which comprises adding a gelatin having 80,000-120,000 of average molecular weight and from 150 to 340 of jelly strength (Bloom, g, 6.multidot.2/3%) to a buffered physiological saline solution comprising an immunogen, mixing the mixture at a low temperature in the range of from 0.degree. to 10.degree. C., warming the mixture at a temperature in the range of from 40.degree. C. to 50.degree. C. to give a dispersion of solid particles in a liquid colloidal solution, pouring the dispersion of solid particles in a liquid colloidal solution into a physiologically non-toxic liquid which is non-compatible with water to give a flexible spherical form, drying the flexible spherical form at a low temperature in the range of from 0.degree. C. to 10.degree. C. to give a solid spherical form which is enteric.
Dependencies are inferred from the claim text.