Regional perfusion catheter with improved drug delivery control

A medical or biological treatment device for supplying a treatment chemical to a region of a physiologic passage, said device comprising:

• a catheter having an outer surface, a distal end and a proximal end and having a bypass flow passage extending from the outer surface of said catheter at a first location between said proximal and distal ends and along the interior of said catheter to an outlet opening at a second location spaced distally from said first location to allow unimpeded low pressure blood or fluid flow to organs downstream of said catheter;
• an inflatable balloon extending around said catheter and secured at said outer surface of said catheter at a third location between said first and second locations;
• a perforated fluid transfer member carried by said catheter and secured at said outer surface of said catheter at a fourth location between said first and third locations, said fluid transfer member being configured to define an annular chamber with said outer surface of said catheter;
• first conduit means communicating with said balloon for supplying an inflation fluid thereto;
• and
• second conduit means communicating with said annular chamber for conducting fluid to and from said annular chamber, wherein said fluid transfer member comprises a perforated sheet of flexible, elastically expandable material, and a supporting element in the form of a self-supporting sheet of perforated material disposed between said sheet of flexible material and said catheter for holding said sheet of flexible material in a position in which it extends radially outwardly from said catheter and for allowing bidirectional fluid flow through the perforations in said sheet of flexible material.

A medical or biological treatment device for supplying a treatment chemical to a region of a physiologic passage, said device comprising:

• a catheter having an outer surface, a distal end and a proximal end and having a bypass flow passage extending from the outer surface of said catheter at a first location between said proximal and distal ends and along the interior of said catheter to an outlet opening at a second location spaced distally from said first location to allow unimpeded low pressure blood or fluid flow to organs downstream of said catheter;
• an inflatable balloon extending around said catheter and secured at said outer surface of said catheter at a third location between said first and second locations;
• a perforated fluid transfer member carried by said catheter and secured at said outer surface of said catheter at a fourth location between said first and third locations, said fluid transfer member being configured to define an annular chamber with said outer surface of said catheter;
• first conduit means communicating with said balloon for supplying an inflation fluid thereto;
• and
• second conduit means communicating with said annular chamber for conducting fluid to and from said annular chamber, wherein:
• said fluid transfer member is a substantially rigid cylindrical body provided with perforations and defining, with said outer surface of said catheter, for restricting fluid flow in the passage an annular chamber;
• said first conduit means comprise a first tube located outside of said catheter and extending from said proximal end;
• and said second conduit means comprise a second tube located outside of said catheter and extending from said proximal end for supplying a treatment chemical to said annular chamber, and a third tube located outside of said catheter and extending from said proximal end for conducting fluid samples from said annular chamber.

A medical or biological treatment device for supplying a treatment chemical to a region of a physiologic passage, said device comprising:

• a catheter having an outer surface, a distal end and a proximal end and having a bypass flow passage extending from the outer surface of said catheter at a first location between said proximal and distal ends and along the interior of said catheter to an outlet opening at a second location spaced distally from said first location to allow unimpeded low pressure blood or fluid flow to organs downstream of said catheter;
• an inflatable balloon extending around said catheter and secured at said outer surface of said catheter at a third location between said first and second locations;
• a perforated fluid transfer member carried by said catheter and secured at said outer surface of said catheter at a fourth location between said first and third locations, said fluid transfer member being configured to define an annular chamber with said outer surface of said catheter;
• first conduit means communicating with said balloon for supplying an inflation fluid thereto;
• second conduit means communicating with said annular chamber for conducting fluid to and from said annular chamber, and an element supported by said outer surface of said catheter and containing a chemical or biological material in a form to be released at a selected rate into a fluid surrounding said catheter.