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US 5,175,430 AGranted
Time-compressed chromatography in mass spectrometry
AssigneeMeridian Instruments, Inc.
InventorsChristie G. Enke, John F. Holland, Richard D. McLane, George E. Yefchak
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Abstract
A process and apparatus employing the time compression of chromatography in mass spectrometry with array detection in which the time compressed informatioin is deconvoluted by mathematical analysis for recovery of analytical information made inaccessible in the time compression and thereby resulting in a decrease in analysis time and improved component identification without loss of sensitivity.
Claims11
A method for reducing the time required in chromatographic analyses comprising the following:
- compression in time of a chromatographic separation of analytes on a chromatographic column resulting in a loss of chromatographic resolution;
- transport of the column eluent into a mass spectrometer ion source;
- generation of ions within the ion source;
- mass analysis by rapid array detection mass spectrometry;
- acquisition and computer processing of said mass spectral information including mathematical deconvolution of overlapping chromatographic peaks;
- and
- said deconvolution constituting recovery of all of the chromatographic analytical information.
4 more elements
A device for time-compressed chromatography comprising:
- a chromatograph having a column and a sample inlet system;
- an interface for transporting the column eluent into a mass spectrometer ion source;
- a mass analyzer capable of high speed array detection;
- a data system for collection, processing, storage, and output of mass spectrometer data files;
- said processing including the execution of algorithms appropriate for the mathematical deconvolution of overlapping chromatographic peaks;
- means to compress said peaks in time whereby losses in resolution produced by said time compression are recovered by the mathematical deconvolution resident in and executed by said data system.
3 more elements
Dependencies are inferred from the claim text.