Virus-resistant transgenic mice
AssigneeOhio University/Edison Animal Biotechnolgy Center
InventorsThomas E. Wagner, Xiao-Zhuo Chen
Life of this patent
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Abstract
A transgenic mouse with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding a human interferon having antiviral activity into a host mouse. The gene encodes the interferon of a different animal species and therefore its expression product is less toxic to the host at an embryonic, fetal, neonatal or junvenile stage of development. Preferably, the human beta interferon gene is introduced into the cells of a mouse.
Claims8
A transgenic mouse whose somatic and germ cells contain and express a gene coding for human beta interferon at a level sufficient to provide antiviral activity in said mouse, said gene having been introduced into said mouse or an ancestor of said mouse at an embryonic stage, and wherein said gene is operably linked to an at least partially constitutive non-interferon promoter.
Dependencies are inferred from the claim text.