Process for preparing cis-dihydronopol
AssigneeKali-Chemie Pharma GmbH
InventorsWalter Heitmann, Uwe Maetzel
Life of this patent
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Abstract
A process for preparing cis-dihydronopol and esters thereof in which corresponding esters of (-)nopol are stereoselectively hydrogenated by heterogeneous hydrogenation in the presence of a platinum, platinum oxide or ruthenium/carbon catalyst, and the resulting cis-dihydronopyl esters optionally may be converted into corresponding alcohols by hydrolysis.
Claims4
A process for preparing a 2-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl)-ethanol derivative corresponding to the formula I ##STR10## in which R represents hydrogen or an acyl group COR.sup.1 in which R.sup.1 denotes lower alkyl or phenyl which is optionally substituted by lower alkyl, lower alkoxy or hydroxyl, wherein an ester corresponding to the formula II ##STR11## in which R.sup.1 has the above meaning, is hydrogenated with hydrogen in the presence of a solid catalyst selected from the group consisting of platinum, platinum oxide and ruthenium/carbon to give a compound corresponding to the formula Ia ##STR12## in which R.sup.1 has the above meaning, and optionally eliminating the COR.sup.1 group from the compound of formula Ia.
Dependencies are inferred from the claim text.