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US 5,175,341 AGranted
Mono ester of dicarboxylic acid and process thereof
AssigneeShionogi & Co., Ltd.
InventorsMitsuaki Ohtani, Takaharu Matsuura
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Abstract
Optically active mono-esters of dicarboxylic acid of the formula III: ##STR1## being useful as intermediates for preparing optically active natural products or medicines; asymmetric synthesis process for preparing thereof being characterized by the reaction of an acid anhydride with an (R)- or (S)-arylacetic acid derivative; and the key substances therefor are also claimed.
Claims1
A pure optically active mono-ester of the following formula:
- ##STR74## wherein X is --CH.sub.2 --;
- Y is --(CH.sub.2).sub.2 or --CH.dbd.CH-- and wherein R.sup.1 is alkyl which may be substituted by alkoxy, halogen, amino, hydroxyamino, alkylamino, or nitro or R.sup.1 is alkenyl, aryl or aralkyl, each of which may be substituted by alkyl, alkoxy, halogen, amino, hydroxyamino, alkylamino or the enantiomer of said carboxylic acid esters of the aforementioned formula.
Dependencies are inferred from the claim text.