Isocarbacyclin derivatives and their pharmaceutically acceptable salts thereof
AssigneeTeijin Limited
InventorsAtsuo Hazato, Toshio Tanaka, Noriaki Okamura, Kiyoshi Bannai, Seizi Kurozumi, Masaaki Suzuki, Ryoji Noyori
Life of this patent
Estimating the term…
Abstract
An isocarbacyclin derivative represented by the following formula [VII'] ##STR1## wherein A represents, a hydrocarbylcarboxylate group, a carboxymethoxycarbonyl group, an amide group, an acyloxymethyl group or a hydroxymethyl group; R.sup.4 represents H, a methyl group or a vinyl group; R.sup.5 represents a (substituted)alkyl group, a phenyl group, a phenoxy group or a cycloalkyl group; R.sup.e22 and R.sup.e32 represent H or a hydroxyprotecting group; n is 0 or 1; and a pharmaceutically acceptable salt thereof.
Claims9
An isocarbacyclin derivative represented by the following formula [VII'] ##STR264## wherein R.sup.4 represents (1) a hydrogen atom, (2) a methyl group of (3) a vinyl group;
- R.sup.5 represents (1) an unsubstituted linear or branched C.sub.3 -C.sub.8 alkyl group which may be interrupted by an oxygen atom, (2) a substituted linear or branched C.sub.1 -C.sub.5 alkyl group in which the substituent is (a) a C.sub.1 -C.sub.6 alkoxy group, (b) phenyl, (c) phenoxy or (d) C.sub.3 -C.sub.10 cycloalkyl group which is unsubstituted or is substituted by a halogen atom, a protected hydroxyl group or a C.sub.1 -C.sub.4 alkyl group (3) a phenyl group which is unsubstituted or is substituted by a halogen atom, a protected hydroxyl group of a C.sub.1 -C.sub.4 alkyl group (4) a phenoxy group which is unsubstituted or is substituted by a halogen atom, a protected hydroxyl group or a C.sub.1 -C.sub.4 alkyl group or (5) a C.sub.3 -C.sub.10 cycloalkyl group which is unsubstituted or is substituted by a halogen atom, a protected hydroxyl group or a C.sub.1 -C.sub.4 alkyl group n is 0 or 1;
- R.sup.e22 and R.sup.e32 are identical or different and each represents a hydrogen atom, a tri(C.sub.1 -C.sub.7)hydrocarbon-silyl group, a group forming an acetal linkage together with the oxygen atom or the hydroxyl or ##STR265## wherein R.sup.c11 represents C.sub.1 -C.sub.10 hydrocarbon group;
- and A represents a group of the formula ##STR266## in which R.sup.b21, R.sup.b22 and R.sup.b23 are identical or different and each represents H or C.sub.1 -C.sub.10 hydrocarbon group;
- a group of the formula ##STR267## in which R.sup.a11 represents a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms, and R.sup.a12 represents a hydrogen atom, a C.sub.1 -C.sub.10 hydrocarbon group or a group of the following formula [B-1] ##STR268## in which R.sup.b11 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, R.sup.b12 represents a hydrogen atom or a C.sub.1 -C.sub.10 hydrocarbon group which may be substituted by --OH, --SH, a lower alkylthio group or an N atom-containing heterocyclic group, and R.sup.b13 represents a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group,
- R.sup.a11 and R.sup.a12 may be bonded to each other to form a ring, and when n is 0 in formula [VII], R.sup.a11 and R.sup.a12 are not simultaneously groups
- selected from H and C.sub.1 -C.sub.10 alkyl groups or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.