Naphthoquinone derivatives
AssigneeBurroughs Wellcome Co.
InventorsAlan T. Hudson, Anthony W. Randall
Life of this patent
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Abstract
Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R.sup.1 is hydrogen and R.sup.2 is selected from C.sub.1-6 alkoxy, aralkoxy, C.sub.1-6 alkyl-C.sub.1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C.sub.1-6 alkyl, halogen and perhalo-C.sub.1-6 alkyl; or R.sup.1 and R.sup.2 are both C.sub.1-6 alkyl or phenyl; and n is 0 or 1) and salt thereof. The compounds of formula (I) are useful for the treatment or prophylaxis of protozoal diseases including malaria, theileriosis and coccidiosis. Various processes for preparing compounds of formula (I) are described.
Claims5
A compound of formula (I) ##STR14## wherein either R.sup.1 is hydrogen and R.sup.2 is selected from C.sub.1-6 alkoxy, aralkoxy, C.sub.1-6 alkyl-C.sub.1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C.sub.1-6 alkyl, halogen and perhalo-C.sub.1-6 alkyl;
- or R.sub.1 and R.sub.2 are both C.sub.1-6 alkyl or phenyl;
- and n is 0 or 1 and X is halogen.
A compound of Formula (I) ##STR15## wherein R.sup.1 is hydrogen and R.sup.2 is a phenyl group substituted by C.sub.1-6 alkyl and optionally substituted by halogen or R.sup.2 is a phenyl group substituted by perhalo-C.sub.1-6 alkyl and optionally substituted by halogen;
- and n is 0 or 1 and X is halogen.
Dependencies are inferred from the claim text.