Method for preparation of taxol using .beta.-lactam
AssigneeFlorida State University
InventorRobert A. Holton
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Abstract
A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and process for the preparation of taxol comprising contacting said .beta.-lactam and an alcohol in the presence of an activating agent to provide a taxol intermediate, and converting the intermediate to taxol.
Claims3
A process for the preparation of taxol comprising reacting a .beta.-lactam with an alcohol in the presence of an activating agent to form an intermediate and converting the intermediate to a taxol, the .beta.-lactam having the formula ##STR13## wherein R.sub.1 and R.sub.3 are phenyl and R.sub.2 is a hydroxy protecting group, and the alcohol having the formula ##STR14## wherein R.sub.4 is a hydroxyl protecting group.
Dependencies are inferred from the claim text.