Preparation process of indoles
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsTadatoshi Honda, Makoto Kotani
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Abstract
A process is provided for the preparation of an indole from aniline or a derivative thereof and a polyhydric alcohol. The reaction is carried out in the presence of a catalyst composed of a carrier having a specific surface area of at least 10 m.sup.2 /g and silver supported on the carrier. The catalyst also contains as an additional component a specific amount of at least one element selected from Co, Fe and Ni. Deterioration in catalytic performance of the catalyst during the reaction and its regeneration are therefore minimized.
Claims13
In a process for preparing an indole compound by reacting an aniline compound selected from the group consisting of aniline, o-toluidine, m-toluidine, p-toluidine, o-haloanilines, m-haloanilines, p-haloanilines, o-aminophenol, m-aminophenol, p-aminophenol, o-anisidine, m-anisidine and p-anisidine with an alcohol selected from the group consisting of ethylene glycol, propylene glycol, 1,2-butanediol, 1,2,4-butanetriol, 2,3-butanediol and diethylene glycol in the presence of a catalyst composed of a carrier having a specific surface area of at least 10 m.sup.2 /g and silver supported on the carrier, the improvement wherein the catalyst further comprises at least one element selected from Co, Fe and Ni, said at least one element being contained in a range of from 0.01 to 0.20 on a basis of the atomic ratio to the silver.
Dependencies are inferred from the claim text.