US 5,175,298 A · Dipeptide hydroxy ethylene isostere synthesis and intermediates therefor

Abstract

The present invention provides processes and intermediates for one preparation of the hydroxy ethylene isostere dipeptide of leu-val which is itself useful in the preparation of renin inhibitory peptides. The process employs certain novel oxazolidenes.

Claims1

Dependent claims

A compound selected from the compounds depicted below:

wherein R is benzyl or tert-butyl.

Dependencies are inferred from the claim text.

Facts

Application

07/623,702Filed 11 Dec 1990 · continuation

Priority

30 Jun 1988

Granted

29 Dec 1992

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07D 307/33
Oxygen atoms: in position 2, the oxygen atom being in its keto or unsubstituted enol form
C07D 263/26
Attached in position 2: with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
C07D 413/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
C07K 5/0207
Containing at least one abnormal peptide link: containing the structure -NH-4-C, e.g. 'isosters', replacing two amino acids

Dipeptide hydroxy ethylene isostere synthesis and intermediates therefor

Life of this patent

Abstract

Claims1

Dipeptide hydroxy ethylene isostere synthesis and intermediates therefor

Life of this patent

Abstract

Claims1