New thiophene compounds as intermediates
AssigneeAdir et Compagnie
InventorsMichel Wierzbicki, Frederic Sauveur, Jacqueline Bonnet, Martine Brisset, Charles Tordjman
Life of this patent
Estimating the term…
Loading patent…
AssigneeAdir et Compagnie
InventorsMichel Wierzbicki, Frederic Sauveur, Jacqueline Bonnet, Martine Brisset, Charles Tordjman
Estimating the term…
New thiophene compounds of the formula: ##STR1## in which: X represents hydrogen, halogen, C.sub.1 -C.sub.5 alkyl or alkoxy or dialkylamino; n represents 1 or 2; a represents an integer of from 2 to 6; b represents 2 or 3; c represents 1 or 2, and is such that b+c=4; R.sub.1 and R.sub.2 represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the carbon atom to which they are bonded form a hydrocarbon ring containing from 3 to 6 carbon atoms; and R and R' represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the nitrogen atom to which they are bonded form a pentagonal or hexagonal heterocycle optionally containing an oxygen atom or a second nitrogen atom which may itself be substituted; and their physiologically tolerable salts. The products of the invention can be used therapeutically especially in the treatment of pathologies that are characterized by a loss of bone tissue. As new intermediate products used in the synthesis of the compounds I above defined, the amides of the formula: ##STR2## in which: X, n, a, b, c, R.sub.1, R.sub.2, R and R' are as above defined.
Amides of the formula V:
Dependencies are inferred from the claim text.