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US 5,175,290 AGranted
8-(oxo-substituted cycloalkyl)xanthines
AssigneeMarion Merrell Dow Inc.
InventorsWaclaw J. Rzeszotarski, Roger N. Hiner, Scott W. Feeney
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Abstract
1,3-Substituted-8-(oxo-substituted cycloalkyl)xanthines and pharmaceutically acceptable salts of such compounds are disclosed. Preferred compounds include the cis and trans isomers of 1,3-dipropyl-8-(3-hydroxycyclopentyl)xanthine and the cis and trans isomers of 1,3-dipropyl-8-(4-hydroxycyclohexyl)xanthine. The compounds are potent and selective bronchodilators and/or cardiotonic agents.
Claims3
A compound of the formula ##STR4## wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, lower alkyl, allyl, carboxyalkyl, carbalkoxyalkyl and aralkyl,
- R.sub.3 is C.dbd.O;
- n is 0 to 7 and
- m is 1 to 7, with the proviso that n and m taken together cannot exceed 7;
- and pharmaceutically acceptable salts of such compounds.
1 more element
Dependencies are inferred from the claim text.