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AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsMasaru Saita, Hisataka Inoue, Terumi Hachiya, Mikio Nakashima, Shigenori Yahiro, Yasuaki Taniguchi, Yoshiki Deguchi, Shoji Hamanaka, Masayoshi Tsuji, Kanji Noda
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A dibenz[b,e]oxepin derivative represented by the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkyl or alkoxy; one of R.sup.3 and R.sup.4 is lower alkoxy, and other is a group represented by the formula (II) ##STR2## wherein R.sup.5 is hydrogen or lower alkyl, A is hydroxyl, --O(CH.sub.2).sub.m --R.sup.6 (wherein m is an integer of 1-6, R.sup.6 is hydrogen, lower alkyl or alkoxy, cycloamino, or lower alkoxycarbonyl), cycloamino, di-lower alkylamino or --NH(CH.sub.2).sub.n --R.sup.7 (wherein n is an integer of 0-3, R.sup.7 is hydrogen, hydroxyl, phenyl, thiazole or cycloamino).
A compound which is a dibenz[b,e]oxepin derivative of formula (I) ##STR49## wherein R.sup.1 and R.sup.2 are each a hydrogen atom, halogen atom, lower alkyl group of lower akoxy group;
An antiphlogistic agent comprising a compound which is a dibenz[b,e]oxepin derivative of formula (1) ##STR53## wherein R.sup.1 1 and R.sup.2 are each a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group, one of R.sup.3 and R.sup.4 is a lower akoxy group, and the other is a group of formula (II) ##STR54## wherein R.sup.5 is a hydrogen atom or lower alkyl group, A is an hydroxyl group, --O(CH.sub.2).sub.m --R.sup.6 wherein m is an integer of 1-6, R.sup.6 is a hydrogen atom, lower alkyl group, lower alkoxy group, piperazino group, morpholino group, piperidino group, pyrrolidino group or lower alkoxycarbonyl group, di-lower alkylamino group or --NH(CH.sub.2).sub.n --R.sup.7 wherein n is an integer of 0-3, R.sup.7 is a hydrogen atom, hydroxyl group, phenyl group, thiazole group, piperazino group, morpholino group, piperidino group or pyrrolidino group.
Dependencies are inferred from the claim text.