Medical grade adhesives and their preparation
AssigneeThe University of Akron
InventorsDaniel J. Smith, Oscar C. Mascarenhas
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Abstract
Crosslinked hydrogel polymers are made by reacting a disubstituted aliphatic diamine of the general formula (I) or (XI) as given in the specification, with one or more diepoxides having the general formula (II), also as given in the specification, and subjecting the resulting non-crosslinked polymer having repeating units of the formula III or XIII to crosslinking conditions to produce the desired crosslinked hydrogel polymer. Hydrogel polymers thus produced are highly hydrophilic with a high degree of water uptake and a high equilibrium water content. In addition, these hydrogel polymers are highly absorptive of fluids and are adhesive when applied to dry surfaces but not when applied to wet surfaces. The hydrogel polymers are useful in wound dressings.
Claims23
A polymer selected from the group consisting of:
- (A) polymers having repeating units of at least one of the following general formulas:
- ##STR14## and (B) blends of such polymers,
- wherein:
- B is a monovalent blocking group;
- R.sub.1 and R.sub.2 are the same or different and each is an alkyl radical of 1 to about 4 carbon atoms or a hydroxyalkyl radical of 2 to about 6 carbon atoms;
- X is an alkylene group having from 2 to about 6 carbon atoms or a dioxyalkylene group having from 2 to about 6 carbon atoms;
- y is a positive integer from 2 to about 6.
A process for preparing a polymer having repeating units selected from the group consisting of :
- (1) units of the general formula III ##STR15## or (2) the general formula XIII;
- ##STR16## or (3) the general formula XVII ##STR17## or (4) mixtures thereof
- wherein B is a monovalent blocking group
- R.sup.1 and R.sup.2 are the same or different and each is an alkyl radical of 1 to about 4 carbon atoms or a hydroxyalkyl radical of 2 to about 4 carbon atoms;
- X is an alkylene group having from 2 to about 6 carbon atoms;
- y is a positive integer from 2 to about 6,
- which comprises reacting (A)
- (1) a substituted diamine compound of the following formula I or mixture thereof
- R.sub.1 NH--(CH.sub.2).sub.y --NHR.sub.2
- or
- (2) a disubstituted diamine of the formula XI ##STR18## or (3) a disubstituted diamine of the formula XVI ##STR19## or (4) a mixture of such disubstituted diamines,
- with (B) one or more difunctional alkylating agents containing from 2 to about 12 carbon atoms.
Dependencies are inferred from the claim text.