Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
OwnerSoorianarain Baligadooinventor
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Abstract
There are disclosed pharmaceutical preparations and methods for the use thereof which have a cardioprotective action useful in coronary insufficiency, in the prevention of the constitution of an infarction or of sudden death. It consists in the utilization of amiodarone, a nitrate derivative and a beta-blocker.
Claims18
A method of providing cardioprotective action to a patient suffering from coronary insufficiency and complications thereof which comprises administering to such patient a cardioprotectively sufficient amount of protective agents comprising at least one member of the group consisting of
- A i) amiodarone in conjunction with
- ii) at least one coronary vasodilator having at least one nitro group selected from the group consisting of isosorbide mononitrate, isosorbide dinitrate, pentaerythrityl tetranitrate, erythrityl tetranitrate and nitroglycerine, and
- B ii) a beta blocker selected from the group consisting of acetbutolol, metoprolol, propranolol and atenolol.
A cardioprotective agent for administration to a patient suffering from coronary insufficiency to thereby reduce the probability of incidence of myocardial infarction in such a patient which comprises a combination selected from the group consisting of
- A i) cardioprotectively sufficient amounts of amiodarone, in the presence of
- ii) at least one coronary vasodilator having at least one nitro group selected from the group consisting of isosorbide mononitrate, isosorbide dinitrate, pentaerythrityl tetranitrate, erythrityl tetranitrate and nitroglycerine, and
- B iii) a beta blocker selected from the group consisting of acetbutolol, metoprolol, propranolol and atenolol, in the presence of
- C iv) a pharmacologically acceptable carrier.
A method of providing cardioprotective action to a patient suffering from coronary insufficiency and complications thereof which comprises administering to such patient a cardioprotectively sufficient amount of protective agents comprising
- A i) amiodarone in conjunction with
- ii) at least one coronary vasodilator having at least one nitro group selected from the group consisting of isosorbide mononitrate, isosorbide dinitrate, pentaerythrityl tetranitrate, erythrityl tetranitrate and nitroglycerine, and
- iii) a beta blocker selected from the group consisting of acetbutolol, metoprolol, propranolol and atenolol.
A cardioprotective agent for administration to a patient suffering from coronary insufficiency to thereby reduce the probability of incidence of myocardial infraction in such a patient which comprises a combination of
- A i) cardioprotectively sufficient amounts of amiodarone, in the presence of
- ii) at least one coronary vasodilator having at least one nitro group selected from the group consisting of isosorbide mononitrate, isosorbide dinitrate, pentaerythrityl tetranitrate, erythrityl tetranitrate and nitroglycerine, and
- B ii) a beta blocker selected from the group consisting of acetbutolol, metoprolol, propranolol and atenolol, in the presence of
- c iv) a pharmacologically acceptable carrier.
Dependencies are inferred from the claim text.