Oxetanones
AssigneeHoffmann-La Roche Inc.
InventorsPierre Barbier, Fernand Schneider, Ulrich Widmer
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AssigneeHoffmann-La Roche Inc.
InventorsPierre Barbier, Fernand Schneider, Ulrich Widmer
Estimating the term…
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently C.sub.1-17 -alkyl which is saturated or optionally interrupted by up to 8 double or triple bonds and/or optionally interrupted by an O or S atom, which is present in other than the .alpha.-position to an unsaturated C atom; or phenyl, benzyl or --C.sub.6 H.sub.4 --X--C.sub.6 H.sub.5 ring-substituted by 0 to 3 C.sub.1-6 -alkyl-(O or S).sub.1 or 0 groups, and X is oxygen, sulfur or (CH.sub.2).sub.0-3, with the proviso that when R.sup.1 is n-hexyl and R.sup.2 is undecyl or 2Z,5Z-undecadienyl, at least one of the asymmetric C-atoms present in the oxetanone ring and in the .beta.-position to the latter has the R-configuration, an enantiomer or a diastereomer thereof are described. These compounds inhibit pancreas lipase and are useful agents in the treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis.
A compound of the formula ##STR25## wherein R.sup.1 and R.sup.2 are independently C.sub.1-17 -alkyl which is saturated or optionally interrupted by up to 8 double or triple bonds and/or optionally interrupted by an O or S atom, which is present in other than the .alpha.-position to an unsaturated C atom;
A pancreas lipase-inhibiting composition comprising an effective amount of a racemic compound of the formula ##STR26## wherein R.sup.1 and R.sup.2 are independently C.sub.1-17 -alkyl which is saturated or optionally interrupted by up to 8 double or triple bonds and/or optionally interrupted by an O or S atom, which is present in other than the .alpha.-position to an unsaturated C. atom;
A composition according to claim 19, wherein R.sup.1 is methyl, propyl, hexyl, decyl, hexadecyl, allyl, benzyl or ethyl;
Dependencies are inferred from the claim text.