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US 5,175,184 AGranted
Benzothiophene derivatives and antihyperuricemia thereof
AssigneeKotobuki Seiyaku Co., Ltd.
InventorsTsuyoshi Tomiyama, Akira Tomiyama, Koichi Kubota
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Abstract
A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic adic derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.
Claims8
A compound of the formula ##STR13## wherein:
- R.sup.1 is lower alkyl;
- R.sup.2 is hydrogen or lower alkyl
- Y is carbonyl,
- B is ##STR14## wherein R.sup.4 is a hydroxy, alkoxy, amino, hydroxylamino, --NHCH.sub.2 CONH.sub.2 --, or NHCH.sub.2 COOR.sup.5 group, wherein R.sup.5 is a lower alkyl group,
- Z.sup.1 and Z.sup.2 are each selected from a hydrogen atom or a lower alkyl group, and
- n is an integer of 1 or 2 and
- pharmaceutically acceptable salts thereof.
4 more elements
Dependencies are inferred from the claim text.