Lipoxygenase inhibiting compounds

A compound of the formula ##STR165## and the pharmaceutically acceptable acid addition salts thereof;

• wherein A is a divalent radical selected from the group consisting of alkylene, of from one to six carbon atoms, alkenylene, of from two to twelve carbon atoms, --(CH.sub.2).sub.m --O--(CH.sub.2).sub.n -- where m and n are independently selected from zero and integers of from one to six, --O--(CH.sub.2).sub.m -- where m is as previously defined
• Ar is ##STR166## where Z is sulfur
• R.sup.8 is one, two, or three substituents independently selected from the group consisting of halogen, cyano, hydroxy, alkyl, halosubstituted alkyl, alkenyl, alkoxy, alkoxyalkyl, alkoxyalkoxyalkyl, cycloalkyl, aryl, aryloxy, aroyl, aralkyl, aralkenyl, aralkoxy, arylthioalkoxy, aralkoxyalkyl, arylthioalkoxyalkyl, heteroaryl, and heteroarylalkyl;
• R.sup.1 and R.sup.2 are independently selected from hydrogen, substituted alkyl, substituted aralkyl, and substituted cycloalkyl wherein the substituents are selected from the group consisting of alkoxy, halo, cyano, amino, carboxyl, hydroxy, --C(O)R.sup.10, --OC(O)R.sup.10, and NHC(O)R.sup.10 where R.sup.10 is selected from the group consisting of alkyl, alkoxy, amino, alkylamino, dialkylamino, and aryl;
• and
• M is selected from hydrogen, a pharmaceutically acceptable cation, and a pharmaceutically acceptable metabolically cleavable group.