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US 5,175,178 AGranted
1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
AssigneeSterling Drug Inc.
InventorsGuy D. Diana, Thomas R. Bailey
Life of this patent
Estimating the term…
Abstract
Compounds of the formulas ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms; R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; and R.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R.sub.8 is hydrogen R' is hydroxy-lower-alkyl, are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
Claims12
A compound of the formula ##STR24## wherein:
- Y is an alkylene bridge of 3-9 carbon atoms;
- R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;
- R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl;
- and
- R.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R.sub.8 is hydrogen R' is hydroxy-lower-alkyl;
- or pharmaceutically acceptable acid-addition salts thereof.
3 more elements
Dependencies are inferred from the claim text.