1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
AssigneeSterling Drug Inc.
InventorsGuy D. Diana, Thomas R. Bailey
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein: Y is alkylene of 3 to 9 carbon atoms; R.sub.1 is lower-alkyl, lower-alkoxy-(C.sub.1-3 -alkyl), lower-alkoxycarbonyl, cyclopropyl or trifluoromethyl; R.sub.2 and R.sub.3 independently are hydrogen, lower-alkyl, halogen, lower-alkoxy, nitro, trifluoromethyl or hydroxy; and R.sub.4 is hydrogen or lower-alkyl; where lower-alkyl and lower-alkoxy, each occurrence, have from 1-5 carbon atoms; with the proviso that when R.sub.1 is lower-alkyl, at least one of R.sub.2 and R.sub.3 is hydroxy; or pharmaceutically acceptable acid-addition salts thereof are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
Claims18
A compound of the formula ##STR17## wherein:
- Y is alkylene of 3 to 9 carbon atoms;
- R.sub.1 is lower-alkyl, lower-alkoxy-(C.sub.1-3 -alkyl), lower-alkoxycarbonyl, cyclopropyl or trifluoromethyl;
- R.sub.2 and R.sub.3 independently are hydrogen, lower-alkyl, halogen, lower-alkoxy, nitro, trifluoromethyl or hydroxy;
- and
- R.sub.4 is hydrogen or lower-alkyl;
- where lower-alkyl and lower-alkoxy, each occurence, have from 1-5 carbon atoms;
- with the proviso that when R.sub.1 is lower-alkyl, at least one of R.sub.2 and R.sub.3 is hydroxy;
- or pharmaceutically acceptable acid-addition salts thereof.
Dependencies are inferred from the claim text.