Antiviral combinations and compounds therefor
AssigneeBurroughs Wellcome Co.
InventorsTodd A. Blumenkopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
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Abstract
The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, espectially viruses of the herpes group.
Claims1
And anti-herpetic composition comprising an amount of a first compound acyclovir and a second compound 2-acetylpyridine 5-((2-pyridylamino)thiocarbonyl) thiocarbonohydrazone, the first and second compounds being present in an amount to provide an anti-herpetic synergistic effect, and the ratio of the first compound to the second compound being 0.5:1 to 50:1 (w/w).
Dependencies are inferred from the claim text.