Triazolyl thioamide derivates
AssigneeEgis Gyogyszergyar
InventorsJozsef Barkoczy, Jozsef Reiter, Laszlo Pongo, Lujza Petocz, Marton Fekete, Frigyes Gorgenyi, Gabor Gigler, Istvan Gacsalyi, Istvan Gyertyan
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AssigneeEgis Gyogyszergyar
InventorsJozsef Barkoczy, Jozsef Reiter, Laszlo Pongo, Lujza Petocz, Marton Fekete, Frigyes Gorgenyi, Gabor Gigler, Istvan Gacsalyi, Istvan Gyertyan
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The invention relates to novel triazolyl thioamides of the general formula (I), ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C.sub.1-4 alkyl substituent(s), or a group of the formula SR.sup.1, wherein R.sup.1 stands for straight or branched chained alkyl group comprising 1 to 6 carbon atom(s), or a group of the formula NR.sup.2 R.sup.3, wherein R.sup.2 and R.sup.3 each represent hydrogen, straight or branched chained C.sub.1-4 alkyl or C.sub.2-6 alkenyl group, Y denotes C.sub.1-4 alkyl optionally bearing one or more hydroxyl or C.sub.1-4 alkoxy substituent(s), phenyl-(C.sub.1-4 alkyl) optionally bearing on the phenyl ring one or more C.sub.1-4 alkoxy group(s), or phenoxy-(C.sub.1-4 alkyl) optionally substituted on the phenyl ring by a C.sub.1-4 alkyl bearing a heterocyclic group containing a nitrogen atom, and pharmaceutically acceptable acid addition salts thereof. Furthermore the invention relates to a process for preparing these compounds. The compounds according to the invention possess tranquillant, antidepressant, spacmolytic, antiinflammatory, analgesic and antiperistaltic effects.
A triazolyl thioamide of the formula (I) ##STR4## wherein Q represents piperazinyl optionally bearing one or more C.sub.1-4 alkyl substituent(s), and
1-[5-amino-3-(4-methy lpiperazinyl)-1H-1,2,4-triazol-1-yl]-N-{3-[3-(1-piperidinylmethyl)phenoxy]p ropyl}-carbothioamide.
Dependencies are inferred from the claim text.