Thiophene compounds and their pharmaceutical uses

A thiophene compound of the formula:

• ##STR23## wherein R.sup.1 is hydrogen, nitro, amino, halogen or C.sub.1-4 alkyl;
• R.sup.2 is hydrogen;
• nitro;
• amino;
• halogen;
• C.sub.1-4 alkyl:
• C.sub.1-4 haloalkyl;
• acyl which is selected from the group consisting of acetyl, propionyl, butyryl, isobutyryl, pivaloyl, phenylacetyl, 3-phenyl-propionyl, 2-phenylpropionyl, benzoyl, 1-naphthoyl, 2-naphthoyl, nicotinoyl, isonicotinoyl, 2-thenoyl, 3-thenoyl, 2-furoyl, 3-furoyl, and the aforementioned acyl which is substituted on the aromatic ring by one substituent selected from the group consisting of halogen, hydroxy, amino, nitro, cyano, C.sub.1-4 alkyl, C.sub.1-4 alkoxy and carboxyl;
• C.sub.2-5 alkoxycarbonyl;
• C.sub.1-4 alkoxy C.sub.1-4 alkyl;
• aryloxy-C.sub.1-4 alkyl;
• acyloxy-C.sub.1-4 alkyl which is selected from the group consisting of acetoxymethyl, propionyloxymethyl, 1- or 2-acetoxyethyl, 1- or 2-propionyloxyethyl, 3-acetoxypropyl, 3-propionyloxypropyl, benzoyloxymethyl, 2-benzoyloxyethyl, 3-benzoyloxypropyl, 4-benzoyloxybutyl;
• hydroxy-C.sub.1-4 alkyl;
• acyloxy-C.sub.2-5 alkanoyl which is selected from the group consisting of acetoxyacetyl, 3-acetoxypropionyl, 4-acetoxybutyryl, benzoyloxyacetyl, 3-benzoyloxypropionyl and 4-benzoyloxybutyryl;
• C.sub.1-4 alkoxy-C.sub.2-5 alkanoyl;
• hydroxy-C.sub.2-5 alkanoyl;
• aryloxy-C.sub.2-5 alkanoyl or C.sub.2-5 haloalkanoyl;
• R.sup.3 is phenyl substituted by one substituent selected from the group consisting of halogen, hydroxy, amino, nitro, cyano, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-5 alkanoylamino, C.sub.1-4 haloalkyl, acetoxy, propionyloxy, butyryloxy, isobutyryloxy or benzoyloxy, C.sub.2-5 alkoxycarbonyl and carboxyl on the aromatic ring;
• m is 0, 1 or 2;
• n is 2;
• and
• the bond represented by .sub.-- is a single bond or a double bond.