Occular hypotensive agents
AssigneeSankyo Company, Limited
InventorsTomihisa Yokoyama, Masaharu Fukami, Mitsuru Kataoka
Life of this patent
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Abstract
Pharmaceutical compositions and methods for treatment of eye disorders employ ocular hypotensive compounds of the formula (I); ##STR1## (wherein: R.sup.1 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy; each R.sup.2 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro or carboxy; R.sup.3 is selected from heterocyclic, amino, mono-substituted amino, and di-substituted amino, A and B each represents C.sub.1 -C.sub.6 alkylene, X represents --NH-- or --CH.sub.2 --; and n is 1, 2 or 3) or pharmaceutically acceptable salts or esters thereof.
Claims21
A method for treatment of eye disorders by the application of an effective amount of an ocular hypotensive compound of the formula (I);
- ##STR5## wherein R.sup.1 is selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, and a C.sub.1 -C.sub.6 alkoxy group;
- each R.sup.2 is the same or different and is selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a halogen atom, a nitro group or a carboxy group;
- R.sup.3 is a heterocyclic group;
- A and B, which may be the same or different, such represents a C.sub.1 -C.sub.6 alkylene group;
- X represents a group of the formula --NH-- or --CH.sub.2 --;
- and
- n represents 1, 2 or 3;
- said heterocyclic groups having 5 to 7 ring atoms, including at least one nitrogen atom, and optionally having 1 to 3 further heteroatoms, and being unsubstituted or having one substituent selected from the group consisting of a C.sub.1 -C.sub.6 group, a C.sub.2 -C.sub.7 aliphatic acyl group, a phenyl group and a substituted phenyl group substituted with a C.sub.1 -C.sub.6 alkyl group;
- a C.sub.1 -C.sub.6 alkoxy group or a halogen atom;
- or a pharmaceutically acceptable salt or ester thereof.
Dependencies are inferred from the claim text.