5 .alpha.-pregnan-20-ones and 5-pregnen-20-ones and related compounds

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound and a pharmaceutical carrier therefor, said compound having the formula:

• ##STR67## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.7, R.sub.8, R.sub.11, R.sub.12, R.sub.13, R.sub.14 and R.sub.15 are each independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.5 and R.sub.6 are independently hydrogen or lower alkyl;
• R.sub.9 and R.sub.10 are each independently hydrogen, lower alkyl or halogen;
• R.sub.16 and R.sub.17 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.18 is hydrogen, lower alkyl, halogen or lower alkoxy;
• or
• R.sub.16 and R.sub.18 taken together with the carbon to which they are attached form an epoxide ring;
• and
• R.sub.19 is hydrogen, lower alkyl, tri-haloloweralkyl, di-haloloweralkyl or mono-haloloweralkyl.

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound and a pharmaceutical carrier therefor, said compound having the formula:

• ##STR86## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.7, R.sub.8, R.sub.11, R.sub.12, R.sub.13, R.sub.14 and R.sub.15 are each independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.5 and R.sub.6 are independently hydrogen or methyl;
• R.sub.9 is hydrogen, lower alkyl or halogen;
• R.sub.16 and R.sub.17 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.18 is hydrogen, lower alkyl, halogen or lower alkoxy;
• or
• R.sub.16 and R.sub.18 taken together with the carbon to which they are attached form an epoxide ring;
• and
• R.sub.19 is hydrogen, lower alkyl, tri-haloloweralkyl, di-haloloweralkyl or mono-haloloweralkyl.

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound and a pharmaceutical carrier therefor, said compound having the formula:

• ##STR87## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.7, R.sub.8, R.sub.11, R.sub.12, R.sub.13, R.sub.14 and R.sub.15 are each independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.5 and R.sub.6 are independently hydrogen or methyl;
• R.sub.9 and R.sub.10 are each independently hydrogen, lower alkyl or halogen;
• R.sub.16 and R.sub.17 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.18 is hydrogen, lower alkyl, halogen or lower alkoxy;
• or
• R.sub.16 and R.sub.18 taken together with the carbon to which they are attached form an epoxide ring;
• and
• R.sub.19 is hydrogen, lower alkyl, tri-haloloweralkyl, di-haloloweralkyl or mono-haloloweralkyl.

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound and a pharmaceutical carrier therefor, said compound having the formula:

• ##STR88## wherein R.sub.5 and R.sub.6 are independently hydrogen or lower alkyl;
• R.sub.16 and R.sub.17 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.18 is hydrogen, lower alkyl, halogen or lower alkoxy;
• or
• R.sub.16 and R.sub.18 taken together with the carbon to which they are attached form a epoxide ring;
• and
• R.sub.19 is hydrogen, lower alkyl, tri-haloloweralkyl, di-haloloweralkyl or mono-haloloweralkyl.

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound and a pharmaceutical carrier therefor, said compound having the formula:

• ##STR90## wherein R.sub.5 and R.sub.6 are independently hydrogen or lower alkyl;
• R.sub.16 and R.sub.17 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy;
• R.sub.18 is hydrogen, lower alkyl, halogen or lower alkoxy;
• or
• R.sub.16 and R.sub.18 taken together with the carbon to which they are attached form an epoxide ring;
• and
• R.sub.19 is hydrogen, lower alkyl, tri-haloloweralkyl, di-haloloweralkyl or mono-haloloweralkyl.