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US 5,175,153 AGranted
Substituted alpha-amino acids having pharmaceutical activity
AssigneeWarner-Lambert Company
InventorsChristopher F. Bigge, James T. Drummond, Vlad E. Gregor, Graham Johnson, Michael R. Pavia
Life of this patent
Estimating the term…
Abstract
The present invention is novel substituted .alpha.-amino acids, pharmaceutical compositions, method of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.
Claims14
A compound of the formula ##STR44## or a pharmaceutically acceptable acid addition, or base salt thereof wherein
- (1) n is 0, 1, or 2;
- (2) R.sup.1, R.sup.2 and R.sup.5 are independently hydrogen or a pharmaceutically acceptable labile ester or amide residue;
- (3) R.sup.3 and R.sup.4 are independently hydrogen, hydroxy, lower alkyl optionally substituted by hydroxy or methoxy, aryl, aralkyl, lower alkoxy, R.sup.10 S(O).sub.0-1 (CH.sub.2).sub.q wherein q is 0, 1, or 2 and R.sup.10 is lower alkyl, halogen, trifluoromethyl, or R.sup.3 and R.sup.4 when on adjacent ring carbons are together --CH.dbd.CH--CH.dbd.CH--;
- (4) R.sup.9 is a hydrogen or a protective group;
- (5) Q is --(CH.sub.2).sub.m ----(CH.dbd.CH)--, --CH.sub.2 --(CH.dbd.CH)--, or (CH.dbd.CH)--CH.sub.2 --wherein m is 0, 1, 2, or 3.
2 more elements
Dependencies are inferred from the claim text.