Method of retarding the progression of chronic renal failure
AssigneeThe Johns Hopkins University
InventorMackenzie Walser
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Abstract
Progression of chronic renal failure can be retarded (slowed or arrested) by administering to humans suffering from such disorder an agent which suppresses the production of glucocorticoids in the human. The agents may be administered alone or in combination with a protein restricted and/or phosphorus restricted diet. Examples of suitable agents which either suppress production of glucocorticoids or block binding to their receptors include sodium valproate, enkephalins, opioids, clonidine, ketoconazole, oxytocin, and mifepristone.
Claims10
A method of retarding the progression of chronic renal failure in humans comprising administering to the human suffering from chronic renal failure an effective amount of an agent which suppresses the endogenous production of glucocorticoids in said human, said agent not including an agent selected from the group consisting of clonidine, heroin, corticosteroids, and alpha-ketoacid analogs of essential or semi-essential amino acids as the sole effective ingredient.
Dependencies are inferred from the claim text.