Adhesive tape preparation of clonidine
AssigneeNitto Denko Corporation
InventorsShoichi Tokuda, Saburo Otsuka, Yuusuke Ito
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Abstract
An adhesive tape preparation of clonidine is disclosed, comprising a polytetrafluoroethylene porous sheet having an air permeability of from 10 to 500 seconds having thereon an active ingredient-containing layer comprising a pressure-sensitive adhesive obtained by copolymerizing a monomer mixture comprising from 40 to 80% by weight of 2-ethylhexyl acrylate, from 20 to 60% by weight of 2-methoxyethyl acrylate, and 0 to 40% by weight of vinyl acetate, the pressure-sensitive adhesive containing clonidine as an active ingredient. The preparation achieves sustained release of clonidine and exhibits long-term preservability while minimizing skin irritation and maintaining sufficient adhesion to the skin.
Claims15
An adhesive tape preparation of clonidine which comprises a polytetrafluoroethylene porous backing having an air permeability of from 10 to 500 seconds having thereon an active ingredient-containing layer comprising a pressure-sensitive adhesive obtained by copolymerizing a monomer mixture comprising from 40 to 80% by weight of 2-ethylhexyl acrylate, from 20 to 60% by weight of 2-methoxyethyl acrylate, and 10 to 40% by weight of vinyl acetate, said pressure-sensitive adhesive containing clonidine as an active ingredient in a concentration of from 1 to 25% by weight based on the active ingredient-containing layer;
- said preparation having a moisture permeability of from 200 to 3000 g/m.sup.2 per 24 hours and a skin irritation index of less than 30.
Dependencies are inferred from the claim text.