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US 5,175,002 AGranted
Amantadine hydrochloride syspension with enhanced dissolution characteristics for use in soft gelatin capsules
AssigneeThe Du Pont Merck Pharmaceutical Company
InventorGeorge Torosian
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Abstract
There are provided, novel no or low wax formulations for amantadine hydrochloride and methods for preparing such formulations.
Claims25
A pharmaceutical dosage form which comprises a soft gelatin capsule for oral administration containing in the hollow interior thereof, a pharmaceutical composition comprising a suspension of the following components:
- (a) a therapeutically effective amount of amantadine hydrochloride;
- (b) a suspending vehicle including a low melting point of wax or lipid or a combination thereof together with a primary vehicle consisting essentially of soybean oil, peanut oil, sesame oil, cottonseed oil, corn oil, sunflower oil, olive oil, safflower oil, or coconut oil, and comprising no greater than 10% of the capsule fill weight;
- (c) at least one emulsifying agent;
- and
- (d) optionally including additional pharmaceutically acceptable excipients.
2 more elements
Dependencies are inferred from the claim text.