Topical drug release system
AssigneeBeecham Group Limited
InventorAdrian F. Davis
Life of this patent
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Abstract
A topical composition containing a dissolved drug or the like (e.g. hydrocortisone acetate) preferably in saturated solution, and a solubilizer (e.g. propylene glycol), and preferably water and an antinucleant, is applied to a water-wetted area of the body, such as the hair or scalp, such that, on mixing with the body water, the resultant drug concentration exceeds the saturated drug solubility in the initially formed resultant mixture, thus giving a supersaturated drug composition.
Claims15
A method for forming a supersaturated drug composition in situ for topical treatment of a human or animal body, which comprises applying to a water-wetted area of the body a composition comprising a carrier system that comprises a solubilizer and a drug dissolved in said carrier system, the amount of the dissolved drug being such that, on mixing of the composition with water on the water-wetted area of the body, the resultant drug concentration in the initially formed resultant mixture is greater than the saturated drug solubility in said resultant mixture, whereby said resultant mixture is supersaturated with the drug.
A drug composition suitable for forming a supersaturated composition in situ when applied to a water-wetted area of a human or animal body, comprising a drug dissolved in a carrier system which contains from 0.01 to 1.0% by weight of an antinucleating agent, based on the total weight of the composition, the carrier system comprising from 0 to 50% by weight of water and from 50 to 100% by weight of a solubilizer, based on the total weight of the carrier system.
A method for forming a supersaturated drug composition in situ for topical treatment of a human or animal body, which comprises applying to a water-wetted area of the body a composition comprising a carrier system that comprises a solubilizer and a drug dissolved in said carrier system, said carrier system comprising from 0 to 50% by weight of water and from 50 to 100% by weight of said solubilizer, based on the total weight of said carrier system, and the amount of the dissolved drug being such that, on mixing of the composition with water on the water-wetted area of the body, the resultant drug concentration in the initially formed resultant mixture is grater than the saturated drug solubility in said resultant mixture, whereby said resultant mixture is supersaturated with the drug.
Dependencies are inferred from the claim text.