Pharmaceutical composition having thrombolytic activity
AssigneeLeuven Research & Development VZW
InventorDesire J. Collen
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Abstract
Plasminogen activators of the tissue-type and plasminogen activators of the urokinase-type appear to have a synergistic action in vivo when administered together as thrombolytic agents. Use in pharmaceutical compositions and in methods for the preparation and use thereof are set forth.
Claims4
A therapeutic composition comprising tissue plasminogen activator (t-PA) and a urokinase plasminogen activator in single-chain, form wherein said t-PA and urokinase plasminogen activator in single-chain form each is present per unit dose in said composition in an amount which results in a synergistic fibrin clot lysing interaction when said therapeutic composition is administered to a mammal having a fibrin clot to be lysed.
A therapeutic composition comprising tissue plasminogen activator (t-PA) and a urokinase plasminogen activator in two-chain form, wherein said t-PA and urokinase plasminogen activator in two-chain form each is present per unit dose in said composition in an amount which results in a synergistic fibrin clot lysing interaction when said therapeutic composition is administered to a mammal having a fibrin clot to be lysed.
Dependencies are inferred from the claim text.