Method of using iron containing preparation for NMR imaging
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsAkihisa Takaichi, Toshihiko Okamoto, Toshiaki Matsumoto, Junji Nakamura, Toshio Nakamura
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Abstract
There is described an iron containing preparation for NMR imaging comprising, as necessary ingredients, the prescribed amounts of an iron containing compound, sodium carbonate or sodium hydrogencarbonate and a neutralizing agent. This preparation is safe, easy to drink, and when taking, provides clear and accurate contrast imaging of inner organs. Further, addition of potassium carbonate to this preparation gives excellent preservation stability.
Claims24
A nuclear magnetic resonance imaging method comprising administering a diagnostically effective amount of a contrast medium to a subject and performing nuclear magnetic resonance tomography on said subject, said contrast medium comprising:
- 0.1 to 10% by weight, as elemental iron, of at least one iron containing compound selected from the group consisting of an iron (II) salt and an iron (III) salt;
- 8 to 60% by weight of at least one of sodium carbonate and sodium hydrogen carbonate;
- and
- 10 to 70% by weight of a neutralizing agent, wherein said neutralizing agent reacts with said at least one of sodium carbonate and sodium hydrogen carbonate to produce carbon dioxide in the alimentary canal of said subject, when orally administered to the subject with water, and wherein the produced carbon dioxide expands and extends the alimentary canal.
A nuclear magnetic resonance imaging method comprising administering a diagnostically effective amount of a contrast medium to a subject and performing nuclear magnetic resonance tomography on said subject, said contrast medium comprising:
- at least one iron containing compound selected from the group consisting of an iron (II) salt and an iron (III) salt
- at least one of sodium carbonate and sodium hydrogen carbonate;
- a neutralizing agent, and
- potassium carbonate as a preservation stabilizing agent;
- wherein said neutralizing agent reacts with said sodium carbonate or sodium hydrogen carbonate to produce carbon dioxide in the alimentary canal of a subject, when administered to said subject together with water, and wherein said produced carbon dioxide expands and extends said alimentary canal of said subject.
Dependencies are inferred from the claim text.