Method of isotope enrichment

A method of isotope enrichment comprising:

• providing a reactant, said reactant being a mixture of at least a first isotopic compound and a second isotopic compound of the same reactant, said first isotopic compound having atoms of a first isotope of an element, said second isotopic compound having atoms of a second isotope of said element, said first and second isotopes of said element being nonionically bonded in said reactant, introducing an electron transfer agent into said reactant isotopic mixture to form a reaction mixture, said electron transfer agent facilitating the transfer of electrons interactive with one or more selected nuclei of said reactant, said electron transfer agent being in an amount sufficient upon reaction of said reaction mixture to establish an electron exchange equilibrium between an electron rich reaction product and an electron poor reaction product and being in an amount insufficient upon reaction of said reaction mixture to drive said reaction to completion, reacting said reaction mixture until said equilibrium is established, and separating said electron poor reaction product from said electron rich reaction product.