Surgical adhesive
AssigneeSanyo Chemical Industries, Ltd.
InventorsTetsuo Itoh, Takehisa Matsuda
Life of this patent
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Abstract
Surgical adhesives, comprising an NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate and a polyol component comprising a polyester polyol derived from an electron-attracting group-containing dicarboxylic acid, such as 2-ketoglutaric acid, are capable of being easily hydrolyzed within a living body after a certain period of time.
Claims19
A surgical adhesive which comprises at least one NCO-terminated hydrophilic urethane prepolymer, derived from (a) an organic polyisocyanate and (b) a polyol component comprising at least one polyester polyol derived from a dicarboxylic acid represented by the general formula:
- HOOC--(A).sub.m --COOH (1)
- wherein m is 0 or 1, A is --CH.sub.2 -- or an electron attracting group represented by the formula:
- --R--CO-- or ##STR2## R is a divalent hydrocarbon group containing 1-8 carbon atoms, R' is a divalent hydrocarbon group or halogen-substituted hydrocarbon group containing 1-8 carbon atoms, X is a halogen atom or nitro or cyano group, Y is hydrogen atom, a halogen atom or nitro or cyano group, n is 0, 1 or 2, wherein the polyester polyols derived from a dicarboxylic acid have an equivalent weight of 20-1000, the ratio of NCO/OH is 1.5 or more, and the NCO content of the NCO-terminated hydrophilic urethane prepolymer is 1-10%.
Dependencies are inferred from the claim text.