Emulsions of highly fluorinated organic compounds
AssigneeHemaGen/PFC
InventorsRobert J. Kaufman, Thomas J. Richard
Life of this patent
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Abstract
Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
Claims16
A physiologically acceptable emulsion comprising a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly water soluble, and a surfactant, wherein
- (a) the highly fluorinated organic compound is present in an amount between about 20% and about 60% by volume and
- (b) the amounts of the surfactant and oil are dependent on the volume percent of highly fluorinated organic compound and are present in amounts effective to produce emulsions characterized by (1) a particle size distribution of less than 400 nm after sterilization, (2) a serum stability characterized by a particle size distribution of less than 400 nm after 5 days in serum or ionic solutions, (3) an LD.sub.50 in rats of at least 16 ml/kg of the highly fluorinated organic compound component of the emulsion, (4) an at least 70% survival upon total exchange in rats and (5) a shelf stability of at least several months at 4.degree. C.
A physiologically acceptable emulsion comprising a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly water soluble, and a surfactant, wherein
- (a) the highly fluorinated organic compound is present in an amount between about 20% and about 60% by volume and
- (b) the amounts of the surfactant and oil are dependent on the volume percent of highly fluorinated organic compound and are present in amounts effective to produce emulsions characterized by (1) a particle size distribution of less than 300 nm after sterilization, (2) a serum stability characterized by a particle size distribution of less than 300 nm after 5 days in serum or ionic solutions, (3) an LD.sub.50 in rats of at least 16 ml/kg of the highly fluorinated organic compound component of the emulsion, (4) an at least 70% survival upon total exchange in rats and (5) a shelf stability of at least several months at 25.degree. C.
Dependencies are inferred from the claim text.