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US 5,171,318 AGranted
Treated corneal prosthetic device
AssigneeChiron Ophthalmics, Inc.
InventorsDavid Gibson, Michael Lerner, Robert Nordquist, Cary Reich
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AssigneeChiron Ophthalmics, Inc.
InventorsDavid Gibson, Michael Lerner, Robert Nordquist, Cary Reich
Estimating the term…
Prosthetic devices are prepared for subepithelial implantation by coating their surfaces with a coating comprising crosslinked or uncrosslinked fibronectin. If the surface of the device comprises a material which does not normally bind fibronectin, it is pretreated, for example, by coating with poly(L-lysine). The coated prosthetic device is implanted by removing a portion of the epithelium, affixing the coated device to the subepithelial tissue optionally replacing all or part of the removed epithelium, and allowing new epithelial tissue to grow over and affix itself to the surface of the prosthetic device. The method of the invention can be used to implant contact lenses permanently beneath the epithelium of the cornea.
A treated corneal prosthetic device for subepithelial implantation in a human or animal cornea comprising a prosthetic device having on its surface a coating comprising crosslinked or uncrosslinked fibronectin or a biologically active fragment or analog of fibronectin, the surface of the prosthetic device comprising a synthetic polymeric material which is pre-treated to chemically modify said material to make it capable of binding said fibronectin, fragment or analog, whereby the coating is supportive for corneal epithelial cells and supports the attachment, growth and migration of corneal epithelial tissues across the surface of the prosthetic device.
A treated corneal prosthetic device for subepithelial implantation in a human or animal cornea comprising a prosthetic device having on its surface a coating comprising crosslinked or uncrosslinked fibronectin, the surface of the prosthetic device comprising a synthetic polymeric material which is pre-treated to chemically modify said material to make it capable of binding said fibronectin, whereby the coating is supportive for corneal epithelial cells and supports the attachment, growth and migration of corneal epithelial tissues across the surface of the prosthetic device.
Dependencies are inferred from the claim text.